A retrospective study of 301 patients with Lyme disease and tick-borne co-infections found that combination antibiotics significantly reduced pain and neurological symptoms, and were generally well tolerated.

This study looked at how pain changes in patients with tick-borne infections after antibiotic treatment. Most saw significant pain reduction, regardless of age or gender. Although some immune biomarkers shifted, they didn’t clearly explain why pain improved. The results support using antibiotics in long-term cases and raise ethical concerns about limiting access to treatment when patients are still suffering.